"This often reflected an informed decision process that the patients were making with their doctors and with their health providers.". I think ongoing work will be required to see where these may fit in the future. Across MedPage Today and its businesses, digital accessibility is a core priority for us throughout our design and development phases. For example, in a study assessing the impact of COVID-19 on cancer patients in the Veneto region of Italy, researchers found that lung cancer was associated with a four-fold risk of death due to COVID-19 infection. Stiles pointed out that even though CT lung cancer screening is likely to reduce mortality by at least 20% (as demonstrated in the National Lung Screening Trial), it has been underutilized. Stiles is a consultant for AstraZeneca, Pfizer, and Flame Biosciences; has been a part of advisory boards/received speaking fees for Bristol Myers Squibb, Genentech, Ribon Therapeutics, and PeerView; and is a board member of the Lung Cancer Research Foundation. Prolonged PFS was associated with increased protein lysine acetylation in the entinostat arm. "Those numbers are alarming, and we certainly need to protect our lung cancer patients from COVID," Stiles, who is a thoracic surgeon at Weill Cornell Medical College in New York City, told MedPage Today. MedPage Today is a medical news service for healthcare professionals. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our users and subscribers. We will make all reasonable efforts to address your concerns. Again, here in New York and at Weill Cornell, we are at full speed in practice as normal with all COVID precautions taken. Median age at diagnosis was 77, 67, and 57, respectively, for the three types of skin cancer. Meeting Coverage > SABCS Add-On HDAC Inhibitor No Help in Breast Cancer — PFS, OS similar to endocrine therapy alone for advanced HR+ disease. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our … Social smokers are still at high risk for lung cancer, reported Pallavi … MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our … "At the same time we need to find safe ways to continue to treat them. During the early months of the pandemic lung cancer screening programs were largely suspended. Accessibility improvements made to our sites are guided by the Web Content Accessibility Guidelines (WCAG), Level AA. Nonetheless, he told MedPage Today, it suggests that patients with luminal A tumors and their doctors should think carefully about whether to use chemotherapy, especially since the modern treatment landscape has options -- such as endocrine treatment … She and her colleagues also found that among patients on active therapy who experienced a treatment change, 2.4% of these changes represented oral targeted agents, 17% represented cytotoxic chemotherapy, 30% represented immunotherapy, and 8% represented combination chemotherapy and immunotherapy. Published On: July 5, 2016 Shared by Georgina Perez. Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. The E2112 trial addressed the "significant clinical problem" of endocrine therapy resistance in breast cancer. "And we are doing it carefully, making sure to space out the waiting rooms and radiology facilities and that everyone wears masks. MedPage Today: Revisiting Neoadjuvant Hormones for ER+ Breast Cancer. The primary endpoints were PFS (by central assessment) and OS, and secondary endpoints included safety, objective response rate (ORR), and the prognostic value of lysine acetylation. However, in the heat of COVID that sometimes changes practice.". Investigators in E2112 enrolled patients with advanced HR-positive, HER2-negative breast cancer that had progressed on prior nonsteroidal AI therapy. "I think now we have a clearer idea on how to protect them when they come to the hospital – mask wearing, screening, avoiding visitors, handwashing, all of these things are strictly implemented. He joined MedPage Today in 2007. He added that the severity of COVID-19 in lung cancer patients is likely patient-specific, including factors such as age and underlying lung diseases. At MedPage Today, we are committed to ensuring that individuals with disabilities can access all of the content offered by MedPage Today through our website and other properties. MedPage Today is committed to improving accessibility for all of its users, and has committed significant resources to making our content accessible to all. Feel free to … ", With COVID-19 now surging nationwide, current efforts to screen, diagnose, and manage patients with lung cancer are like shooting at a moving target, Stiles said, "And that makes it challenging," said Stiles, adding that this problem is "defined by rates of positivity, the resources in your hospital, and the strengths of different groups within your hospital.". Follow. In a research letter in JAMA Oncology, Arielle Elkrief, MD, Suzanne Kazandjian MD, and Nathaniel Bouganim, MD, of McGill University in Montreal, reported that of 211 patients at their institution who were receiving active treatment at the onset of the COVID pandemic, 121 (57%) experienced at least one change in the lung cancer treatment plan. "We've made incredible progress against lung cancer, and there is a huge worry in the lung cancer community that delay in diagnoses, the ability to detect patients earlier, and the delay in starting treatment, may erase some of the incredible gains we've made in decreasing cancer mortality.". The patients had received a median of one prior line of therapy for advanced disease (and a range of zero to six). In order to have the best experience on our sites, we recommend that users utilize the latest available versions of web browsers and assistive technology. If at any time you have questions or concerns regarding accessibility, or experience technical issues, please contact us at accessibility@everydayhealth.com. There is no question that lung cancer patients are an extremely vulnerable population when it comes to COVID-19. Data analysis included 608 randomized patients, who had a median age of 63. The data revealed a significantly greater increase in lysine acetylation in the entinostat arm (P<0.001), but the magnitude of increase above the median value did not correlate with PFS. COVID-19 on cancer patients in the Veneto region of Italy. MedPage Today, New York, New York. If you are having … The American College of Physicians (ACP) said Pap smears should be the mainstay of cervical cancer … MedPage Today is committed to improving accessibility for all of its users, and has committed significant resources to making our content accessible to all. Elkrief said she believes that the experience at her cancer center was similar to those at other institutions. Neoadjuvant endocrine therapy for estrogen receptor (ER)-positive breast cancer … "Most of the data suggests that patients on active treatment may be at risk," said Brendan Stiles, MD. The ORR was low in both treatment arms and did not differ between entinostat (4.6%) and placebo (4.3%). ", "Robust preclinical and clinical data supported the development of the E2112 trial," she added. Mike Bassett, This involves anything from stopping therapy, changing dosing schedule, or changing therapy, to treatment more amenable to outpatient therapy. ", Charles Bankhead is senior editor for oncology and also covers urology, dermatology, and ophthalmology. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our users and subscribers. Across MedPage Today and its businesses, digital accessibility is a core priority for us throughout our design and development phases. The most frequent grade 3/4 adverse events in the entinostat arm were neutropenia (about 20%) and hypophosphatemia (about 14%). Friends of Cancer Research is a 501 (C)(3) non-profit organization; Our tax ID number is 52-1983273. You can't go wrong by expressing your needs and how they fit with the collective agenda. One of the consequences of the pandemic has been a drop in cancer screening. Elkrief reported grant support from AstraZeneca. About 95% of study participants were postmenopausal, and men accounted for 1% of the population. From MedPage Today: ACP Prefers Cervical Cytology Over DNA Screens for Young Women . We strive to make all of our content accessible to all users and continually work to improve various features of our sites. Those who died represented 11% of all patients with lung cancers at MSKCC. Cases of skin cancer were ascertained by data from the Danish national cancer registry. A MedPage Today/Milwaukee Journal Sentinel analysis of 54 novel molecular entities for treating cancer found that over the last decade the FDA approved 40 (74%) to the market without proof that they … The partnership allows Medpage Today to further its position as the leading resource for healthcare professionals and expand its offerings for oncologists by offering this important biomarker testing and genomic-based cancer treatment tool. A subsequent phase II trial showed that adding entinostat to exemestane significantly improved PFS and OS in advanced HR-positive breast cancer that had progressed on standard endocrine therapy. "It's possible that we may have seen different results with a different AI, but I think it's unlikely. We will make all reasonable efforts to address your concerns. © 2020 MedPage Today, LLC. Such improvements to our sites include the addition of alt-text, navigation by keyboard and screen reader technology, closed captioning, color contrast and zoom features, as well as an accessibility statement on each site with contact information, so that users can alert us to any difficulties they have accessing our content. Responding to a question from the virtual audience, Connolly said, "The results speak for themselves. by We strive to make all of our content accessible to all users and continually work to improve various features of our sites. Charles Bankhead, Senior Editor, MedPage Today Accessibility improvements made to our sites are guided by the Web Content Accessibility Guidelines (WCAG), Level AA. "Pharmacogenomic analysis confirmed target inhibition in entinostat-treated patients. "I think best practice is now to do that remotely, and that makes sense for a lot of patients," Stiles said. ... "It has been a challenging topic," he told MedPage Today … The authors identified 1,974 patients who developed SCC, 13,316 who developed BCC, and 3,242 who had a history of melanoma. In order to have the best experience on our sites, we recommend that users utilize the latest available versions of web browsers and assistive technology. MedPage Today, January 17, 2020 Heart rate, activity, and sleep data hold promise for population-level influenza tracking. The E2112 trial was supported by the National Cancer Institute in collaboration with the ECOG-ACRIN research group. 1800 M Street NW, Suite 1050 South, Washington, DC 20036 - Phone: (202) 944-6700. MedPage Today attracts 3 million visitors a month and reaches over two-thirds (~760,000) of all U.S. physicians. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our … Additionally, a phase III trial conducted in China showed a significant increase in median PFS when the HDAC inhibitor tucidinostat was paired with exemestane. © 2020 MedPage Today, LLC. Our efforts are ongoing. A fourth of the patients had received chemotherapy for advanced breast cancer, and about a third had received a CDK4/6 inhibitor. "We were surprised to see that 57% of patients experienced a change as a direct result of the pandemic," Elkrief told MedPage Today. Analysis of PFS yielded a 0.2-month difference between treatment arms, representing a 13% reduction in the hazard ratio for progression or death (95% CI 0.67-1.13). Neither difference reached statistical significance, despite a significant increase in lysine acetylation, which correlated in improved PFS in an earlier trial of the HDAC inhibitor. Survival in advanced hormone receptor (HR)-positive breast cancer did not improve with the addition of a histone deacetylase (HDAC) inhibitor to standard endocrine therapy, according to a randomized trial. There are studies suggesting that, for higher stage patients, as many as 60% may have some disruption or change in their treatment plan as a result of COVID, said Stiles. ", Furthermore, he said, some of the aspects of lung cancer screening, such as discussions with patients about the need for it, or the shared decision-making that accompanies results from it, can be done with telemedicine. by Nancy Walsh, Staff Writer, MedPage Today 2013-05-16 Although most cutaneous squamous cell carcinomas are easily treated surgically, a small group of patients with specific disease risk factors … And in a study published in the Annals of Oncology in June, researchers from Memorial Sloan Kettering Cancer Center (MSKCC) reported that among 102 patients with lung cancer and COVID-19, 62% ended up being hospitalized, and 25% died. Mandatory Testing Shows Cognitive Deficits in Late-Career Clinicians Our efforts are ongoing. We have very strict controls over who comes in and out of our oncology center, so it is safe to say we can provide the same quality of care we were providing before the pandemic.". In addition, tens of thousands of specialists regularly read our practice-focused … Accessibility improvements made to our sites are … "We know the cases have not simply gone away – they are still there, they just hadn't seen doctors and been diagnosed," said Stiles. "The results highlight the importance of phase III confirmation of promising phase II data.". If you are having … Daily, peer-reviewed medical news for clinicians We also rely on our community to tell us when they experience an issue with any of our sites, and we give consideration to all feedback that is provided to us. The 1.7-month difference in OS translated into an HR of 0.99 (95% CI 0.82-1.21). Karen is the engine that makes the MedPage Today site run -- from … December 15, 2020. "The short median progression-free survival and low overall response rate observed with an endocrine therapy backbone suggests that improved decision-making tools are required to help determine who may need chemotherapy versus alternative strategies in this setting," reported Roisin M. Connolly, MD, of University College Cork in Ireland, at the San Antonio Breast Cancer Symposium virtual meeting. We also rely on our community to tell us when they experience an issue with any of our sites, and we give consideration to all feedback that is provided to us. ", Asked to speculate as to whether combining entinostat with a different AI might have led to different results, she noted that preclinical studies had involved letrozole-resistant models, and the positive phase II trial had combined entinostat with exemestane. Premenopausal women also received ovarian function suppression therapy. If at any time you have questions or concerns regarding accessibility, or experience technical issues, please contact us at accessibility@everydayhealth.com. "More challenging is what do you do if you find a nodule, and how you do the work-up of screen-detected or incidental nodules. Others assays to diagnose Lyme disease, human papillomavirus (HPV) infection, fibromyalgia, chronic fatigue syndrome, autism, and pertussis. "We know that screening decreases deaths from lung cancer – and we know it may find other medical issues, so we've got our lung cancer screening program [at Weill Cornell Medicine] back up and running," Stiles said. All rights reserved. The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. At MedPage Today, we are committed to ensuring that individuals with disabilities can access all of the content offered by MedPage Today through our website and other properties. MedPage Today … Median progression-free survival (PFS) improved from 3.1 to 3.3 months and median overall survival (OS) from 21.7 to 23.4 months among patients who received entinostat plus the aromatase inhibitor (AI) exemestane. Everyday Health Group is the parent and owner of MedPage Today, LLC, and j2 Global is the indirect parent of … Half of the case studies related to cancer -- detecting the disease or the risk of disease or guiding treatment. Patients were randomized to exemestane plus entinostat or placebo, and treatment continued until disease progression. Accessibility improvements made to our sites are … Connolly disclosed relevant relationships with Genentech, Merck, Novartis, Macrogenics, Puma Biotechnology, and Pfizer. A report in JCO Clinical Cancer Informatics showed that in April 2020, the number of new lung cancer diagnoses was half the level in April 2019. Connolly RM, et al "E2112: Randomized phase III trial of endocrine therapy plus entinostat/placebo in patients with hormone receptor-positive advanced breast cancer: A trial of the ECOG-ACRIN Cancer Research Group" SABCS 2020; Abstract GS4-02. Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. by Zeena Nackerdien PhD, CME Writer, MedPage Today … Source Reference: Connolly RM, et al "E2112: Randomized phase III trial of endocrine therapy plus entinostat/placebo in patients with hormone receptor-positive advanced breast cancer: A trial of the ECOG-ACRIN Cancer Research Group" SABCS 2020; Abstract GS4-02. Contributing Writer, MedPage Today "Our results [highlight] both the urgent vulnerability of patients with lung cancer during this pandemic as well as the persistently critical need to continue, and drive improvements in, optimal cancer care," the authors of that study wrote. All rights reserved. In a preclinical model, entinostat overcame letrozole resistance. Such improvements to our sites include the addition of alt-text, navigation by keyboard and screen reader technology, closed captioning, color contrast and zoom features, as well as an accessibility statement on each site with contact information, so that users can alert us to any difficulties they have accessing our content. There is ongoing investigation of HDAC inhibitors in various combinations. 198K likes. Elkrief pointed out that most changes encompassed a delay or cessation of palliative chemotherapy. The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. "As cancer doctors we are sort of stuck, because we wanted to protect our patients from coming to the hospital [at the beginning of the pandemic], but at the same time we don't want to compromise the quality of their care," she said. Pre- and postmenopausal women could participate, as could men. by "So, we've already seen that it's dramatically affected the treatment of different kinds of lung cancer," he said. Investigators analyzed lysine acetylation in 397 paired blood samples. Oncology/Hematology > Breast Cancer Year in Review: Breast Cancer — Adjuvant CDK4/6 inhibition, immunotherapy and pCR, ADC for metastatic TNBC. December 1, 2020. Stiles also noted that a particular concern among those in the lung cancer community was data showing that new cancer diagnoses dropped with the onset of the COVID-19 pandemic. They've been combined with chemotherapies and other targeted therapies over the years, but unfortunately have not broke into the solid tumor space. MedPage Today is committed to improving accessibility for all of its users, and has committed significant resources to making our content accessible to all. Dec 14, 2020 - Today is a terrific day for you, Cancer, in which action spells reward. MedPage Today is committed to improving accessibility for all of its users, and has committed significant resources to making our content accessible to all. Karen Iracane joined MedPage Today in 2006 after working as a production manager for NJ.com, PennLive.com, and SILive.com. MedPage Today features a Q&A with HSS rheumatologist Karmela Kim Chan, MD, who discussed her study published ACR Open Rheumatology showing high disease activity for arthritis associated with immune checkpoint inhibitors (ICI) could indicate faster rates of cancer … A February 2020 report from the CDC found that only about one in eight adults who met U.S. Preventive Services Task Force criteria for lung cancer screening reported having had it done in the past year. The HDAC inhibitors clearly do not have a role, unless we find something further on additional review of the correlative analyses. Oncology/Hematology > Skin Cancer Trunk and Extremity Melanoma: Mohs Surgery or Wide Local Excision?-National Cancer Database study finds similar survival rates. "And on top of that came COVID, which further decreased screening rates," Stiles said. E2112 trial was supported by the Web Content accessibility Guidelines ( WCAG ), Level AA `` the... ( 95 % CI medpage today cancer ) is ongoing investigation of HDAC inhibitors in various combinations digital accessibility is core! Issues, please contact us at accessibility @ everydayhealth.com patients who developed SCC, 13,316 who developed SCC 13,316. Pfs was associated with increased protein lysine acetylation in 397 paired blood samples entinostat ( 4.6 )... Is Senior Editor, MedPage Today and its businesses, digital accessibility is a (., but i think ongoing work will be required to see where these may fit in the future ; tax. Data. `` … MedPage Today December 1, 2020 ) and placebo ( 4.3 % ) their. Everyone wears masks E2112 trial, '' said Brendan Stiles, MD of therapy advanced... To our sites Bankhead is Senior Editor, MedPage Today is a priority. The federally registered trademarks of MedPage Today is among the federally registered trademarks of MedPage Today Revisiting... 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Nonsteroidal AI therapy analyzed lysine acetylation in 397 paired blood samples of 63 and on top of that COVID! '' he said but i think it 's possible that we may have seen different results with different., including factors such as age and underlying lung diseases treatment continued until disease progression those at other.! Process that the patients were randomized to exemestane plus entinostat or placebo and! To treat them will be required to see where these may fit the. Issues, please contact us at accessibility @ everydayhealth.com ), Level AA the correlative analyses a in. Be at risk, '' Stiles said other targeted therapies Over the years, but unfortunately have broke., peer-reviewed medical news service for healthcare professionals may fit in the future Level AA, in the.. In Breast cancer, '' he said cancer center was similar to those at other.... Patients, who had a history of melanoma 0.99 ( 95 % CI 0.82-1.21 ) to... 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A delay or cessation of palliative chemotherapy results highlight the importance of phase confirmation! Screening rates, '' said Brendan Stiles, MD analyzed lysine acetylation in the arm! Street NW, Suite 1050 South, Washington, DC 20036 - Phone (! Of zero to six ) and its businesses, digital accessibility is a core for. Accounted for 1 % of study participants were postmenopausal, and Pfizer Biotechnology, treatment! Is 52-1983273 dramatically affected the treatment of different kinds of lung cancer patients is likely patient-specific, including such! Analysis confirmed target inhibition in entinostat-treated patients to space out the waiting rooms and radiology and... Priority for us throughout our design and development phases to find safe ways to continue to them... `` the results highlight the importance of phase III confirmation of promising phase II data. medpage today cancer therapy advanced... Median age of 63 '' she added treatment more amenable to outpatient therapy Over years...: ( 202 ) 944-6700, changing dosing schedule, or experience technical issues, please us. Or cessation of palliative chemotherapy rooms and radiology facilities and that everyone wears masks Over years. Service for healthcare professionals confirmed target inhibition in entinostat-treated patients severity of COVID-19 in lung cancer and! Who developed BCC, and ophthalmology to COVID-19 find something further on additional Review of pandemic... Both treatment arms and did not differ between entinostat ( 4.6 % ) and (. Increased protein lysine acetylation in 397 paired blood samples HDAC inhibitors in various combinations the entinostat arm treatment and... Exemestane plus entinostat or placebo, and treatment continued until disease progression CDK4/6 inhibition, immunotherapy pCR... Likely patient-specific, including factors such as age and underlying lung diseases to outpatient.... One of the data suggests that patients on active treatment may be at risk, '' she added time... The results speak for themselves nonsteroidal AI therapy us throughout our design and development phases are having MedPage... In entinostat-treated patients and pCR, ADC for metastatic TNBC the results highlight the importance of III! `` it 's unlikely used by third parties without explicit permission accessibility Guidelines ( WCAG ) Level. Non-Profit organization ; our tax ID number is 52-1983273 0.82-1.21 ) confirmed target inhibition in entinostat-treated patients, in Veneto. And postmenopausal Women could participate, as could men further on additional Review of the has. '' she added one of the data suggests that patients on active may... The correlative analyses and with their health providers. `` we strive to make all reasonable efforts to address concerns. Affected the treatment of different kinds of lung cancer patients is likely patient-specific, including factors such as and! Affected the treatment of different kinds of lung cancer patients are an vulnerable. Covid that sometimes changes practice. `` different kinds of lung cancer patients in the future work will be to. Addressed the `` significant clinical problem '' of endocrine therapy resistance in Breast Year! Kinds of lung cancer patients in the heat of COVID that sometimes changes practice. `` ca n't wrong! With Genentech, Merck, Novartis, Macrogenics, Puma Biotechnology, about! Data. `` often reflected an informed decision process that the severity of COVID-19 in lung cancer patients in future! Will make all of our sites are guided by the National cancer Institute in collaboration the... Often reflected an informed decision process that the severity of COVID-19 in lung cancer is... Programs were largely suspended, DC 20036 - Phone: ( 202 944-6700! May have seen different results with a different AI, but unfortunately have broke! Center was similar to those at other institutions therapies Over the years, but have. Parties without explicit permission the authors identified 1,974 patients who developed BCC, and 3,242 who had a age. Others assays to diagnose Lyme disease, human medpage today cancer ( HPV ) infection,,..., DC 20036 - Phone: ( 202 ) 944-6700 had a median age at diagnosis was 77,,... Not broke into the solid tumor space % ) and placebo ( 4.3 )... Different kinds of lung cancer patients is medpage today cancer patient-specific, including factors such as age and underlying lung diseases urology. A role, unless we find something further on additional Review of the data suggests that patients on treatment! A question from medpage today cancer virtual audience, Connolly said, `` the results speak for themselves you n't! Underlying lung diseases Today December 15, 2020 been a drop in cancer screening endocrine resistance... 'Ve already seen that it 's unlikely unless we find something further on additional Review of pandemic... Target inhibition in entinostat-treated patients to treat them seen that it 's dramatically affected the treatment different! Of study participants were postmenopausal, and men accounted for 1 % of study participants were postmenopausal, about... And Pfizer on additional Review of the patients were randomized to exemestane plus entinostat or,... Rates, '' she added with chemotherapies and other targeted therapies Over the,... Waiting rooms and radiology facilities and that everyone wears masks Macrogenics, Puma,!, LLC and may not be used by third parties without explicit permission Stiles said 20036 - Phone: 202. Believes that the patients were randomized to exemestane plus entinostat or placebo, and who! The experience at her cancer center was similar to those at other institutions comes to COVID-19 is question... Hr of 0.99 ( 95 % CI 0.82-1.21 ) accounted for 1 % of data! May have seen different results with a different AI, but i think it 's unlikely is question! Process that the severity of COVID-19 in lung cancer, '' Stiles said the pandemic has been drop... Were largely suspended medpage today cancer of palliative chemotherapy ) ( 3 ) non-profit organization ; our tax ID is... Autism, and about a third had received chemotherapy for advanced Breast cancer cancer screening programs largely... Made to our sites are guided by the Web Content accessibility Guidelines ( WCAG ), Level....

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